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KAI Pharmaceuticals Closes Series A Financing Round at $28 Million
October 26, 2004

Funds to support clinical and preclinical development into 2006

South San Francisco, CA – October 26, 2004 – KAI Pharmaceuticals Inc., an emerging drug discovery and development company, announced today the completion of an $11 Million closing of its Series A financing round, bringing the total amount raised since inception to $28 Million.  Participants in the Series A financing included Skyline Ventures, InterWest Partners, Intersouth Partners, Delphi Ventures, Thomas Weisel Venture Partners, and MDS Capital. 

This financing extends KAI’s financial runway into 2006 and provides the resources needed to fund the ongoing Phase I/II trial of KAI-9803, a program that has received ‘Fast Track’ designation from the FDA for the treatment of reperfusion injury following acute myocardial infarction, or heart attack. In addition, KAI will continue to pursue its preclinical programs and expand its management team.

“We have an experienced and highly respected group of investors that bring strategic value to KAI in addition to financial support,” said Steve James, president and CEO of KAI Pharmaceuticals.  “I would like to welcome our new investors, Thomas Weisel Venture Partners and MDS Capital, as well as thank all of our investors for sharing in KAI’s vision to develop important human therapeutics based upon modulation of specific protein kinase C (PKC) isozymes.”

“PKC isozymes have been promising targets for drug discovery based on their involvement in the regulation of disease pathways. However, the challenge has been to target the PKC isozyme of interest without affecting similar isozymes in the PKC family,” said Yasunori Kaneko, M.D. of Skyline Ventures and Chairman of KAI’s Board of Directors.  “KAI has been able to overcome this major roadblock in kinase regulation with proprietary methods to develop specific inhibitors and activators for each isozyme in the PKC family.”

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About KAI Pharmaceuticals
KAI Pharmaceuticals is a drug discovery and development company with clinical and preclinical therapeutic programs for the acute treatment of ischemia and reperfusion injury and for diseases involving chronic regulation of angiogenesis.  The company is applying its core expertise in the biology of specific protein kinase C (PKC) isozymes to develop highly specific activators and inhibitors of PKC isozymes for the treatment of a variety of human diseases. KAI has received ‘Fast Track’ designation for its lead drug candidate, KAI-9803, currently being investigated in a Phase I/II clinical trial as a treatment to reduce reperfusion injury as an adjunct to current treatments for acute myocardial infarction, or heart attack.  KAI Pharmaceuticals is based in South San Francisco, California, and can be found online at www.KAIpharma.com.