Key peer-reviewed publications relating to KAI’s proprietary selective PKC modulation technology: 

Aley, K. O., R. O. Messing, et al. (2000). "Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C." J Neurosci 20(12): 4680-5.

Bates, E., C. Bode, et al. (2008). "Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction." Circulation 117(7): 886-96.

Bright, R., A. P. Raval, et al. (2004). "Protein kinase C delta mediates cerebral reperfusion injury in vivo." J Neurosci 24(31): 6880-8.

Chen, L., H. Hahn, et al. (2001). "Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC." Proc Natl Acad Sci U S A 98(20): 11114-9.

Harrison, S., K. Das, et al. (2008). "Non-ATP-competitive kinase inhibitors - enhancing selectivity through new inhibition strategies " Expert Opinion on Drug Discovery 3(7): 761-774.

Inagaki, K., L. Chen, et al. (2003). "Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo." Circulation 108(19): 2304-7.

Inagaki, K., H. S. Hahn, et al. (2003). "Additive protection of the ischemic heart ex vivo by combined treatment with delta-protein kinase C inhibitor and epsilon-protein kinase C activator." Circulation 108(7): 869-75.

Inagaki, K., T. Koyanagi, et al. (2008). "Pharmacological Inhibition of {epsilon}-Protein Kinase C Attenuates Cardiac Fibrosis and Dysfunction in Hypertension-Induced Heart Failure." Hypertension.

Lee, J. S. and J. Y. Ro (2007). "Peripheral metabotropic glutamate receptor 5 mediates mechanical hypersensitivity in craniofacial muscle via protein kinase C dependent mechanisms." Neuroscience 146(1): 375-83.

Mochly-Rosen, D. (1995). "Localization of protein kinases by anchoring proteins: a theme in signal transduction." Science 268(5208): 247-51.

Mochly-Rosen, D. and A. S. Gordon (1998). "Anchoring proteins for protein kinase C: a means for isozyme selectivity." Faseb J 12(1): 35-42.

Qi, X., K. Inagaki, et al. (2008). "Sustained pharmacological inhibition of deltaPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats." J Clin Invest 118(1): 173-82.

Roe, M. T., E. M. Ohman, et al. (2001). "Shifting the open-artery hypothesis downstream: the quest for optimal reperfusion." J Am Coll Cardiol 37(1): 9-18.

Schmitz-Peiffer, C., D. R. Laybutt, et al. (2007). "Inhibition of PKCvarepsilon Improves Glucose-Stimulated Insulin Secretion and Reduces Insulin Clearance." Cell Metab 6(4): 320-8.

Shumilla, J. A., T. Liron, et al. (2005). "Ethanol withdrawal-associated allodynia and hyperalgesia: age-dependent regulation by protein kinase C epsilon and gamma isoenzymes." J Pain 6(8): 535-49.

Souroujon, M. C. and D. Mochly-Rosen (1998). "Peptide modulators of protein-protein interactions in intracellular signaling." Nat Biotechnol 16(10): 919-24.

Suzuki, T., A. Seth, et al. (2008). "Role of phospholipase Cgamma-induced activation of protein kinase Cepsilon (PKCepsilon) and PKCbetaI in epidermal growth factor-mediated protection of tight junctions from acetaldehyde in Caco-2 cell monolayers." J Biol Chem 283(6): 3574-83.

Yellon, D. M. and J. M. Downey (2003). "Preconditioning the myocardium: from cellular physiology to clinical cardiology." Physiol Rev 83(4): 1113-51.